Nome: Quimioterapia Combinada no Tratamento de Crianças com Tumores Progressivos do Cérebro
Categoria: Ensaios Neurofibromatose Tipo 1
Sub Categoria: Glioma Ótico
Recrutando: Sim
Escopo: Internacional
Localizacao: PI: Dr. Joann AterThe University of Texas MD Anderson Cancer CenterHouston, TX AL, AZ, AR, CA, CO, CT, DC, FL, GA, HA, IL, IA, KS, LA, ME, MD, MA, MI, MN, MS, MO, NE, NH, NJ, NM, NY, NC, OH, OK, OR, PA, RI, SC, TN, TX, UT, VT, VA, WA, WV, WI, Austral
Patrocinador: National Cancer Institute (NCI) / Grupo de Oncologia Pediátrica / Grupo de Câncer Infantil
Objetivo: ANÁLISE RACIONAL : As drogas usadas em quimioterapia usam diferentes meios de impedirem as células do tumor de se dividirem e assim elas param de crescer ou morrem. A combinação de mais de uma droga pode matar mais células de tumor.
OBJETIVO; Experimento aleatório fase III para determinar a efetividade da combinação de quimioterapia no tratamento de crianças que têm astrocitomas de baixo grau ou outros tumores residuais do cérebro.
Condição
Recorrente Glioma infantil da base do cérebro
Recorrente Glioma infantil das vias ópticas
Recorrente Astrocitoma cerebral infantil
Recorrente Astrocitoma cerebelar infantil
Tratamento ou Intervenção
Droga: carboplatin
Droga: lomustine
Droga: procarbazine
Droga: thioguanine
Droga: vincristine
Fase III
MEDLINEplus tópicos relacionados: Cancer (General)
Tipo: Tratamento
Intuito:
Titulo Oficial: Fase III Estudo de Carboplatin e Vincristine Versus Thioguanine, Procarbazine, Lomustine, e Vincristine em Crianças com Astrocitoma de baixo grau.
Detalhes: OBJETIVOS:
I. Comparar o simples episódio de sobrevivência como um resultado do tratamento com carboplatin e vincristine versus thioguanine, procarbazine, lomustine e vincristine em crianças com tumores cerebrais progressivos.
II. Avaliar o índice de resposta a cada regime de quimioterapia nestes pacientes.
III. Determinar os efeitos tóxicos e a qualidade de vida das crianças tratadas com cada regime de quimioterapia.
IV. Investigar fatores biológicos e clínicos que possam prever resposta do tumor e progressão precoce (tamanho do tumor, localização, subtipo patológico, citogenética e índice de proliferação por MIB-1 (Ki67)) nestes pacientes.
V. Investigar os fatores contribuintes para a condição neuropsicológica e endócrina de crianças com tumores cerebrais tratadas sem irradiação.
RESUMO DO PROTOCOLO:
Este é um estudo aleatório. Os pacientes são estratificados de acordo com a situação da moléstia, condição no ingresso e patologia. Os pacientes são aleatoriamente selecionados para uma das duas armas de tratamento. Pacientes com neurofibromatose não são aleatoriamente determinados para a arma II.
Arma I : Os pacientes recebem indução com carboplatina e vincristine por 10 semanas seguidas de 2 semanas de descanso. A indução é seguida de 8 procedimentos de manutenção começando no 84º dia de indução ou recuperação hematopoietica. Cada procedimento consiste de 4 doses semanais de carboplatina e 3 doses semanais de vincristine (dados concomitantemente com as 3 semanas de carboplatina), seguidos de 2 semanas de descanso.
Arma II Os pacientes recebem thioguanine oral, procarbazine e lomustine nos dias 0-4, seguidos de vincristine IV nos dias 14 e 28. O tratamento continua a cada 6 semanas por um máximo de 8 procedimentos.
Critérios Inclusao: Idades Habilitáveis para o estudo: até 9 anos
--Características da moléstia—
Astrocitomas residuais de baixo grau patologicamente confirmados ou outros tumores residuais qualificados de cérebro interpretados como de baixo grau (Organização Mundial de Saúde graus I e II) tais como tumores Neurogliais, tumores Astrocíticos, astrocitoma de baixo grau (variantes: fibrilados, protoplasmáticos, gemistociticos)astrocinoma pilocítico ,xantoastrocitomas pleomorficos, astrocitoma subependimal de células gigantes, astrocitoma desmoplástico infantil Tumores oligodentrogliais de baixo grau, oligodendrooglioma de baixo grau gliomas mistos aligo astrocinoma de baixo grau Tumores Neuronais Ganglioglinoma (excluindo tumores com componentes astrocítico anaplásticos) Ganglioglioma desmoplástico infantil , tumor quiasmático-hipolalamico sem confirmação histológica
Todos os seguintes testes de diagnóstico (radiológico ou evidência clínica de progressão, cirurgia ou confirmação IRM devem ser executados dentro de 6 semanas de alistamento para este estudo).
Enfermidade progressiva após excisão cirúrgica baseada em clara evidência de progressão tanto radiológica como clínica , ou uma excisão incompleta (menos de 95% ou maior do que 1,5cm²) com necessidade de se iniciar tratamento por causa de um risco de deterioração neurológica com progressão.
Lesões quiasmáticas que têm extensões contíguas de tumor em outras regiões das vias visuais demonstradas em contraste IRM serão habilitáveis para o estudo sem confirmação histopatológica.
Pacientes com neurofibromatose que têm diagnósticos radiográficos de tumor quiasmático-hipotalamico são habilitáveis para o estudo sem necessidade de confirmação por biópsia de histologia de tumor, mas não a menos que a progressão seja radiologicamente documentada
Tumores não intrínsecos da base do cérebro das pontes ou isolados tumores do nervo óptico sem envolvimento definitivo do quiasma óptico.
--Terapia Anterior/Concomitante—
Terapia Biológica: não especificada
Quimioterapia: Nenhuma quimioterapia para o tumor
Terapia Endócrina : Terapia corticosteróide anterior permitida
Cirurgia: Excisão anterior necessária
Outras: Terapia diurética anterior permitida
--Características do Paciente—
Idade: Abaixo de 10 anos
Condição de desempenho: não especificada
Expectativa de vida: não especificada
Hematopoietica: Contagem absoluta de neutrophil maior do que 1.000/mm³ (armaII) Contagem de plaquetas maior do que 100.000/mm³ (arma II)
Hepatica : não especificado
Renal: Creatinina menos do que 1,5 vezes o limite superior do normal para a idade Ou cleareande de Creatinina ou radioisotopo GFR maior do que 70 mL/min ou equivalente GFR como determinado pela variação institucional normal .
Critérios Exclusao:
Número Participantes: Um total de 280-340 pacientes será atendido no decurso de 4 anos.
Localização / Informações : Victoria, Australia
Royal Children's Hospital, Parkville, Victoria, 3052, Australia; Recrutando
David Ashley 03-9345-5522
Western Australia, Australia
Princess Margaret Hospital for Children, Perth, Western Australia, 6001, Australia; Recrutando
David Baker 011-618-9340-8234
Alberta, Canada
Alberta Children's Hospital, Calgary, Alberta, T2T 5C7, Canada; Recrutando
Max J. Coppes 403-229-7396
Cross Cancer Institute, Edmonton, Alberta, T6G 1Z2, Canada; Recrutando
Beverly Ann Bell 780-432-8512
British Columbia, Canada
British Columbia Children's Hospital, Vancouver, British Columbia, V6H 3V4, Canada; Recrutando
Paul C.J. Rogers 604-875-2322
Nova Scotia, Canada
IWK Grace Health Centre, Halifax, Nova Scotia, B3J 3G9, Canada; Recrutando
Dorothy R. Barnard 902-428-8291
Ontario, Canada
Children's Hospital of Eastern Ontario, Ottawa, Ontario, K1H 8L1, Canada; Recrutando
Jacqueline Halton 613-737-2370
Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada; Recrutando
Victor S. Blanchette 416-598-5852
McMaster Division, Hamilton, Ontario, L8N 3Z5, Canada; Recrutando
Ronald D. Barr 905-521-2100
Quebec, Canada
Centre Hospitalier de L'Universite Laval, Sainte Foy, Quebec, GIV 4G2, Canada; Recrutando
Yvan Samson 418-656-4141
Hopital Sainte Justine, Montreal, Quebec, H3T 1C5, Canada; Recrutando
Albert Moghrabi 514-345-4969
Montreal Children's Hospital, Montreal, Quebec, H3H 1P3, Canada; Recrutando
V. Michael Whitehead 514-934-4322
Netherlands
Academisch Ziekenhuis Groningen, Groningen, 9713 EZ, Netherlands; Recrutando
Willem A. Kamps 31-50-3614213
Puerto Rico
San Jorge Childrens Hospital, Santurce, 00912, Puerto Rico; Recrutando
Luis Antonio Clavell 787-728-1575
Switzerland
Centre Hospitalier Universitaire Vaudois, Lausanne, CH-1011 Suiça; Recrutando
Maja Nenadov Beck 011-41-21-314-1111
Clinique de Pediatrie, Geneva, 1211, Switzerland; Recrutando
Pierre Wacker 41-22-382-47-12
Swiss Pediatric Oncology Group Bern, Bern, CH 3010, Switzerland; Recrutando
Annette Ridolfi Luthy 011-41-31-6329372
Alabama
MBCCOP - University of South Alabama, Mobile, Alabama, 36688, United States; Recrutando
Marcel E. Conrad 334-460-7194
University of Alabama Comprehensive Cancer Center, Birmingham, Alabama, 35294, United States; Recrutando
Robert P. Castleberry, Jr. 205-939-9285
Arizona
Arizona Cancer Center, Tucson, Arizona, 85724, United States; Recrutando
John J. Hutter, Jr. 520-626-8278
Arkansas
University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, United States; Recrutando
David L. Becton 501-320-1497
California
Children's Hospital and Health Center, San Diego, California, 92123-4282, United States; Recrutando
Richard Kadota 858-576-5811
Children's Hospital Los Angeles, Los Angeles, California, 90027-0700, United States; Recrutando
Paul S. Gaynon 323-669-2163
Children's Hospital of Orange County, Orange, California, 92668, United States Recrutando
Wei-Ping Violet Shen 714-532-8628
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, 90095-1781, United States; Recrutando
Stephen A. Feig 310-825-6708
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California, 95051-5386, United States; Recrutando
Carolyn Lucille Russo 408-236-5028
Kaiser Permanente-Southern California Permanente Medical Group, San Diego, California, 92120, United States; Recrutando
Wellington Loh, Jr. 619-516-6144
Long Beach Memorial Medical Center, Long Beach, California, 90806, United States; Recrutando
Jerry Z. Finklestein 310-492-1062
Lucile Packard Children's Hospital at Stanford, Palo Alto, California, 94304, United States; Recrutando
Michael P. Link 650-723-5535
Sutter Cancer Center, Sacramento, California, 95816, United States; Recrutando
Yung Soon Yim 916-733-1757
UCSF Cancer Center and Cancer Research Institute, San Francisco, California, 94115-0128, United States; Recrutando
Katherine K. Matthay 415-476-0603
University of California Davis Medical Center, Sacramento, California, 95817, United States; Recrutando
Jonathan M. Ducore 916-734-2782
University of California San Diego Cancer Center, La Jolla, California, 92093-0658, United States; Recrutando
Faith H. Kung 619-543-6222
Colorado
Children's Hospital of Denver, Denver, Colorado, 80218, United States; Recrutando
Lorrie F. Odom 303-861-6773
Connecticut
Yale Comprehensive Cancer Center, New Haven, Connecticut, 06520-8028, United States; Recrutando
G. Peter Beardsley 203-785-4640
District of Columbia
Children's National Medical Center, Washington, District of Columbia, 20010-2970, United States; Recrutando
Gregory H. Reaman 202-884-2147
Walter Reed Army Medical Center, Washington, District of Columbia, 20307-5000, United States; Recrutando
E. Glenn Edwards 202-782-0421
Florida
All Children's Hospital, St. Petersburg, Florida, 33701, United States; Recrutando
Jerry L. Barbosa 813-892-4176
Baptist Hospital of Miami, Miami, Florida, 33176-2197, United States; Recrutando
Doured Daghistani 305-274-1662
CCOP - Florida Pediatric, Tampa, Florida, 33682-7757, United States; Recrutando
James L. Talbert 352-392-3739
Children's Hospital of Southwest Florida, Fort Myers, Florida, 33908, United States; Recrutando
Emad K. Salman 941-432-3321
Miami Children's Hospital, Miami, Florida, 33155, United States; Recrutando
Enrique A. Escalon 305-662-8360
Nemours Children's Clinic, Jacksonville, Florida, 32207, United States; Recrutando
Eric Sandler 904-390-3793
Shands Hospital and Clinics, University of Florida, Gainesville, Florida, 32610-100277, United States; Recrutando
Paulette Mehta 352-392-5633
St. Mary's Hospital, West Palm Beach, Florida, 33407, United States; Recrutando
Narayana Gowda 407-844-6363
Sylvester Cancer Center, University of Miami, Miami, Florida, 33136, United States; Recrutando
Stuart R. Toledano 305-585-5635
University of Miami-Jackson Memorial Hospital Medical Center, Miami, Florida, 33136, United States; Recrutando
Stuart R. Toledano 305-585-5635
Walt Disney Memorial Cancer Institute, Orlando, Florida, 32803, United States; Recrutando
Clifford Allen Selsky 407-303-2080
Georgia
Emory University Hospital - Atlanta, Atlanta, Georgia, 30322, United States; Recrutando
Andrew M. Yeager 404-727-4451
Hawai
Cancer Research Center of Hawaii, Honolulu, Hawaii, 96813, United States; Recrutando
Robert Warren Wilkinson 808-942-8144
Tripler Army Medical Center, Honolulu, Hawaii, 96859-5000, United States; Recrutando
Ronald David Prauner 808-433-6057
Illinois
CCOP - Illinois Oncology Research Association, Peoria, Illinois, 61602, United States; Recrutando
John W. Kugler 309-671-5180
Children's Memorial Hospital, Chicago, Chicago, Illinois, 60614, United States; Recrutando
Susan Lerner Cohn 773-880-4562
Christ Hospital, Oak Lawn, Illinois, 60453, United States; Recrutando
Sharad N. Salvi 708-346-4094
Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, 60612, United States; Recrutando
Laura Maxwell Pirich 312-942-3059
Saint Jude Midwest Affiliate, Peoria, Illinois, 61602, United States; Recruiting
John A. McCallister 309-672-4945
University of Chicago Cancer Research Center, Chicago, Illinois, 60637, United States; Recrutando
James B. Nachman 773-702-6808
Indiana
Indiana University Cancer Center, Indianapolis, Indiana, 46202-5265, United States; Recrutando
Philip Paul Breitfeld 317-274-8982
Iowa
University of Iowa Hospitals and Clinics, Iowa City, Iowa, 52242, United States; Recrutando
Raymond Tannous 319-356-1905
Kansas
CCOP - Wichita, Wichita, Kansas, 67214-3882, United States; Recrutando
Henry Edward Hynes 316-685-2221
University of Kansas Medical Center, Kansas City, Kansas, 66160-7357, United States; Recrutando
Robert C. Trueworthy 913-588-6340
Via Christi Regional Medical Center, Wichita, Kansas, 67214, United States; Recrutando
David Rosen 316-263-4311
Louisiana
CCOP - Ochsner, New Orleans, Louisiana, 70121, United States; Recrutando
Carl G. Kardinal 504-842-3910
MBCCOP - LSU Medical Center, New Orleans, Louisiana, 70112, United States; Recrutando
Robert Woody Veith 504-568-5843
Tulane University School of Medicine, New Orleans, Louisiana, 70112, United States; Recrutando
Charles Scher 504-588-5412
Maine
Eastern Maine Medical Center, Bangor, Maine, 04401, United States; Recrutando
Sam W. Lew 207-973-7520
Maine Children's Cancer Program, Portland, Maine, 04101, United States; Recrutando
Craig A. Hurwitz 207-885-7565
Maryland
Johns Hopkins Oncology Center, Baltimore, Maryland, 21231, United States; Recrutando
Cindy Schwartz 410-955-2457
Marlene & Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, 21201, United States; Recrutando
Allen E. Eskenazi 410-328-2808
Massachusetts
Boston Floating Hospital Infants and Children, Boston, Massachusetts, 02111, United States; Recrutando
Cynthia S. Kretschmar 617-636-5535
Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States; Recrutando
Holcombe Edwin Grier 617-632-3971
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, 02114, United States; Recrutando
Howard J. Weinstein 617-724-3315
University of Massachusetts Memorial Medical Center, Worcester, Massachusetts, 01655, United States; Recrutando
Molly R. Schwenn 508-856-4225
Michigan
Children's Hospital of Michigan, Detroit, Michigan, 48201, United States; Recrutando
Yaddanapudi Ravindranath 313-745-5649
Hurley Medical Center, Flint, Michigan, 48503, United States; Recrutando
Susumu Inoue 810-762-7303
St. John's Hospital and Medical Center, Detroit, Michigan, 48236, United States; Recrutando
Hadi Sawaf 313-343-3481
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109-0752, United States; Recrutando
Raymond J. Hutchinson 313-936-8785
Minnesota
Mayo Clinic Cancer Center, Rochester, Minnesota, 55905, United States; Recrutando
Carola A.S. Arndt 507-284-3903
University of Minnesota Cancer Center, Minneapolis, Minnesota, 55455, United States; Recrutando
Joseph P. Neglia 612-626-2778
Mississippi
Keesler Medical Center - Keesler AFB, Keesler AFB, Mississippi, 39534-2576, United States; Recrutando
James Allen French, II 228-377-6524
University of Mississippi Medical Center, Jackson, Mississippi, 39216-4505, United States; Recrutando
Dale Jeanette Pullen 601-984-5220
Missouri
Cardinal Glennon Children's Hospital, Saint Louis, Missouri, 63104, United States; Recrutando
Donna Ann Wall 314-577-5638
Children's Mercy Hospital - Kansas City, Kansas City, Missouri, 64108, United States; Recrutando
Maxine L. Hetherington 816-234-3265
University of Missouri-Columbia Hospital and Clinics, Columbia, Missouri, 65212, United States; Recrutando
Hazem Helmy Mahmoud 573-882-3961
Washington University School of Medicine, Saint Louis, Missouri, 63110, United States; Recrutandoi
Lori Luchtman-Jones 314-454-6018
Nebraska
University of Nebraska Medical Center, Omaha, Nebraska, 68198-3330, United States; Recrutando
Peter F. Coccia 402-559-7257
New Hampshire
Norris Cotton Cancer Center, Lebanon, New Hampshire, 03756, United States; Recrutando
Eric Christian Larsen 603-646-5541
New Jersey
CCOP - Northern New Jersey, Hackensack, New Jersey, 07601, United States; Recrutando
Richard J. Rosenbluth 201-996-5800
Hackensack University Medical Center, Hackensack, New Jersey, 07601, United States; Recrutando
Michael B. Harris 201-996-5437
New Mexico
University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131, United States; Recrutando
Jami Frost 505-272-4461
New York
Herbert Irving Comprehensive Cancer Center, New York, New York, 10032, United States; Recrutando
Mitchell S. Cairo 212-305-8316
Kaplan Cancer Center, New York, New York, 10016, United States; Recrutando
Aaron R. Rausen 212-263-7144
Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, United States; Recrutando
Peter G. Steinherz 212-639-7951
Mount Sinai School of Medicine, New York, New York, 10029, United States; Recrutando
Steven Arkin 516-562-4634
Roswell Park Cancer Institute, Buffalo, New York, 14263-0001, United States; Recrutando
Martin L. Brecher 716-845-2333
Schneider Children's Hospital, New Hyde Park, New York, 11042, United States; Recrutando
Arlene Sara Redner 718-470-3460
State University of New York - Upstate Medical University, Syracuse, New York, 13210, United States; Recrutando
Ronald L. Dubowy 315-464-7534
State University of New York Health Sciences Center - Stony Brook, Stony Brook, New York, 11790-7775, United States; Recrutando
Robert Ingalls Parker 631-689-6000
University of Rochester Cancer Center, Rochester, New York, 14642, United States; Recrutando
Barbara Lawrence Asselin 716-275-2981
North Carolina
Carolinas Medical Center, Charlotte, North Carolina, 28232-2861, United States; Recrutando
Daniel P. McMahon 704-355-1130
Comprehensive Cancer Center of Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, 27157-1082, United States; Recrutando
Allen R. Chauvenet 336-716-4085
Duke Comprehensive Cancer Center, Durham, North Carolina, 27710, United States; Recrutando
Philip Martin Rosoff 919-684-3401
East Carolina University School of Medicine, Greenville, North Carolina, 27858-4354, United States; Recrutando
Charles Daeschner, III 919-816-4676
Lineberger Comprehensive Cancer Center, UNC, Chapel Hill, North Carolina, 27599-7295, United States; Recrutando
Stuart Gold 919-966-1178
Memorial Mission Hospital, Asheville, North Carolina, 28801, United States; Recrutando
Orren Beaty, III 823-213-1740
Presbyterian Healthcare, Charlotte, North Carolina, 28233-3549, United States; Recrutando
Donna J. Girard 704-384-4188
Ohio
Children's Hospital Medical Center - Cincinnati, Cincinnati, Ohio, 45229-3039, United States; Recrutando
Robert J. Wells 513-636-4266
Children's Hospital of Columbus, Columbus, Ohio, 43205-2696, United States; Recrutando
Frederick B. Ruymann 614-722-3564
Ireland Cancer Center, Cleveland, Ohio, 44106-5065, United States; Recrutando
Eric Kodish 216-844-3345
Oklahoma
Natalie Warren Bryant Cancer Center, Tulsa, Oklahoma, 74136, United States; Recrutando
Gregory Kirkpatrick 918-494-2525
Oklahoma Memorial Hospital, Oklahoma City, Oklahoma, 73126-0307, United States; Recrutando
William H. Meyer 405-271-4412
Oregon
CCOP - Columbia River Program, Portland, Oregon, 97213, United States; Recrutando
Keith S. Lanier 503-203-1000
Doernbecher Children's Hospital, Portland, Oregon, 97201-3098, United States; Recrutando
H. Stacy Nicholson 503-494-1543
Legacy Emanuel Hospital and Health Center, Portland, Oregon, 97227, United States; Recrutando
Sarah J. Fryberger 503-413-2560
Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States; Recrutando
Beverly J. Lange 215-590-2249
Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, 15213, United States; Recrutando
Arthur Kim Ritchey 412-692-5949
St. Christopher's Hospital for Children, Philadelphia, Pennsylvania, 19134-1095, United States; Recrutando
Gregory E. Halligan 215-427-5000
Rhode Island
Rhode Island Hospital, Providence, Rhode Island, 02903, United States; Recrutando
Edwin N. Forman 401-444-5171
South Carolina
Children's Hospital of Greenville Hospital System, Greenville, South Carolina, 29605, United States; Recrutando
Cary Ernest Stroud 864-455-8898
Medical University of South Carolina, Charleston, South Carolina, 29425-0721, United States; Recrutando
Joseph Laver 803-792-2957
Tennessee
James H. Quillen College of Medicine, Johnson City, Tennessee, 37614-0622, United States; Recrutando
David K. Kalwinsky 423-433-6200
Saint Jude Children's Research Hospital, Memphis, Tennessee, 38105-2794, United States; Recrutando
Ching-Hon Pui 901-495-3335
Vanderbilt Cancer Center, Nashville, Tennessee, 37232-6838, United States; Recrutando
James A. Whitlock 615-936-1762
Texas
Baylor College of Medicine, Houston, Texas, 77030, United States; Recrutando
C. Philip Steuber 713-770-4200
Cook Children's Medical Center - Fort Worth, Fort Worth, Texas, 76104, United States; Recrutando
William Paul Bowman 817-885-4006
Driscoll Children's Hospital, Corpus Christi, Texas, 78466, United States; Recrutando
Judith K. Mullins 361-694-5311
MBCCOP - South Texas Pediatric, San Antonio, Texas, 78284-7810, United States; Recrutando
Anthony J. Infante 210-567-5265
Medical City Dallas Hospital, Dallas, Texas, 75230, United States; Recrutando
Carl Lenarsky 972-566-6647
San Antonio Military Pediatric Cancer and Blood Disorders Center, Lackland Air Force Base, Texas, 78236-5300, United States; Recrutando
Linda G. Shaffer 210-292-5684
Scott and White Clinic, Temple, Texas, 76508, United States; Recrutando
Lawrence S. Frankel 254-724-2006
Simmons Cancer Center - Dallas, Dallas, Texas, 75235-9154, United States; Recrutando
George R. Buchanan 214-648-8594
Texas Oncology, P.A., Dallas, Texas, 75230-2503, United States; Recrutando
Carl Lenarsky 972-566-6647
University of Texas - MD Anderson Cancer Center, Houston, Texas, 77030, United States; Recrutando
R. Beverly Raney, Jr. 713-792-6624
University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78284-7811, United States; Recrutando
Paul Jan Thomas 210-567-5265
University of Texas Medical Branch, Galveston, Texas, 77555-1329, United States; Recrutando
Kwesi Sackey 409-772-2341
Utah
Huntsman Cancer Institute, Salt Lake City, Utah, 84132, United States; Recrutando
William L. Carroll 801-588-2680
Vermont
Vermont Cancer Center, Burlington, Vermont, 05401-3498, United States; Recrutando
Joseph D. Dickerman 802-656-2296
Virginia
Cancer Center, University of Virginia HSC, Charlottesville, Virginia, 22908, United States; Recrutando
Pedro A. De Alarcon 804-924-5105
Carilion Roanoke Community Hospital, Roanoke, Virginia, 24029, United States; Recrutando
Joan Mistretta Fisher 540-985-8055
Inova Fairfax Hospital, Falls Church, Virginia, 22046, United States; Recrutando
Jay N. Greenberg 703-876-9111
Massey Cancer Center, Richmond, Virginia, 23298-0037, United States; Recrutando
Edward Clifton Russell 804-828-9605
Naval Medical Center, Portsmouth, Portsmouth, Virginia, 23708-2197, United States; Recrutando
Paulette Charese Bryant 804-398-5767
Washington
Children's Hospital and Regional Medical Center - Seattle, Seattle, Washington, 98105, United States; Recrutando
J. Russell Geyer 206-526-2106
Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, United States; Recrutando
Jean E. Sanders 206-667-4348
Madigan Army Medical Center, Tacoma, Washington, 98431-5000, United States; Recrutando
Kelly Faucette 253-968-1864
West Virginia
West Virginia University Hospitals, Morgantown, West Virginia, 26506-9162, United States; Recrutando
Frank G. Keller 304-293-1217
West Virginia University Medical School, Charleston Division, Charleston, West Virginia, 25304, United States; Recrutando
Elizabeth M. Kurczynski 304-388-1540
Wisconsin
Midwest Children's Cancer Center, Milwaukee, Wisconsin, 53226, United States; Recrutando
Bruce M. Camitta 414-456-4118
St. Vincent Hospital, Green Bay, Wisconsin, 54307-3508, United States; Recrutando
Jon Brandt 920-433-8670
University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin, 53792, United States; Recrutando
Diane Puccetti 608-263-0320
Study chairs ou investigadores principais:
Joann Ater, Study Chair
Grupo de Câncer Infantil
Maiores / Informações : Study ID Numbers: 199/12467; CCG-A9952; CCG-9952
NLM Identificador: NCT00002944
Data do início do estudo: 8 de abril de 1997
Ùltima Atualização: 1 de setembro de 2000
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